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SELECTED PUBLICATIONS

  1. Caldarelli, P., Deininger, L., Zhao, S., Panda, P., Yang, C., Mikut, R., & Zernicka-Goetz, M. (2025). AI-based approach to dissect the variability of mouse stem cell-derived embryo models. Nature communications, 16(1), 1772.

  2. Hu W, Sancho-Serra C, Gantner CW, Szafranska HM, Solanky N, Metcalfe K, Vento-Tormo R, Zernicka-Goetz M. (2025) Atlas of amnion development during the first trimester of human pregnancy. Nature Cell Biology 27(7):1175-1185. doi: 10.1038/s41556-025-01696-9. PMID: 40659869; PMCID: PMC12270915.

  3. Bulletti Francesco M., Sciorio Romualdo, Conforti Alessandro, De Luca Roberto, Bulletti Carlo, Palagiano Antonio, Berrettini Marco, Scaravelli Giulia, Pierson Roger A. (2025) Causes of embryo implantation failure: A systematic review and meta-analysis of procedures to increase embryo implantation potential. Frontiers in Endocrinology (15) doi:10.3389/fendo.2024.1429193

  4. Adamson, G. D., Creighton, P., de Mouzon, J., Zegers-Hochschild, F., Dyer, S., & Chambers, G. M. (2025). How many infants have been born with the help of assisted reproductive technology?. Fertility and Sterility, 124(1), 40–50.

  5. Junyent, S., Meglicki, M., Vetter, R., Mandelbaum, R., King, C., Patel, E. M., Iwamoto-Stohl, L., Reynell, C., Chen, D. Y., Rubino, P., Arrach, N., Paulson, R. J., Iber, D., & Zernicka-Goetz, M. (2024). The first two blastomeres contribute unequally to the human embryo. Cell, 187(11), 2838–2854.e17.

  6. Zhou, H., Lin, S., Watson, M., Bernadt, C. T., Zhang, O., Liao, L., Govindan, R., Cote, R. J., & Yang, C. (2024). Length-scale study in deep learning prediction for non-small cell lung cancer brain metastasis. Scientific reports, 14(1), 22328. doi.org/10.1038/s41598-024-73428-2

  7. Cao R, Shen C, Yang C. (2024) High-resolution, large field-of-view label-free imaging via aberration-corrected, closed-form complex field reconstruction. Nature Communications 15(1):4713. doi: 10.1038/s41467-024-49126-y. PMID: 38830852; PMCID: PMC11148160.

  8. The Human Fertilisation and Embryology Authority (HFEA). Fertility Treatment 2023: trends and figures report. 2025. Accessed 18 Jul 2025.

  9. World Health Organization. Infertility prevalence estimates 1990-2021. (2023).

  10. Cimadomo, D., Rienzi, L., Conforti, A., Forman, E., Canosa, S., Innocenti, F., et al. (2023). Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis. Hum. Reprod. Update 29 (5), 570–633. doi:10.1093/humupd/dmad010

  11. Shen, C., Lamba, A., Zhu, M., Zhang, R., Zernicka-Goetz, M., & Yang, C. (2022). Stain-free detection of embryo polarization using deep learning. Scientific reports, 12(1), 2404.

  12. Zhu, M., Shahbazi, M.N., Martin, A., Zhang, C., Sozen, B., Borsos, M., Mandelbaum,R.S., Paulson,R.J., Mole,M.A., Esbert,M., et al. (2021). Human embryo polarization requires plc signaling to mediate trophectoderm specification. eLife 10, e65068. 

  13. Ashary, N., Tiwari, A., and Modi, D. (2018). Embryo implantation: war in times of love. Endocrinology 159 (2), 1188–1198. doi:10.1210/en.2017-03082

  14. Horstmeyer R, Chung J, Ou X, Zheng G, Yang C. (2016) Diffraction tomography with Fourier ptychography. Optica 3(8):827-835. doi: 10.1364/OPTICA.3.000827. PMID: 28736737; PMCID: PMC5521281.

  15. Morris, S.A., Teo, R.T.Y., Li, H., Robson, P., Glover, D.M., and Zernicka Goetz, M. (2010). Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo. Proc. Natl. Acad. Sci. USA 107, 6364–6369. 

  16. Ajduk A, Biswas Shivhare S, Zernicka-Goetz M. (2014) The basal position of nuclei is one pre-requisite for asymmetric cell divisions in the early mouse embryo. Dev Biol. 392(2):133-40. doi: 10.1016/j.ydbio.2014.05.009. Epub 2014 May 20. PMID: 24855000; PMCID: PMC4111899.

  17. Ajduk, A., Ilozue, T., Windsor, S., Yu, Y., Seres, K. B., Bomphrey, R. J., Tom, B. D., Swann, K., Thomas, A., Graham, C., & Zernicka-Goetz, M. (2011). Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability. Nature Communications, 2, 417.

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IB Demeter II Ltd.

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Cambridge, UK​

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